Understanding HIV-1 protease autoprocessing for novel therapeutic development
نویسندگان
چکیده
منابع مشابه
Autoprocessing: an essential step for the activation of HIV-1 protease.
Human immunodeficiency virus type 1 (HIV-1) expresses its structural and functional proteins within Gag-Pol precursor polyproteins. Specific proteolytic processing of the precursors by the viral protease is critical for the maturation and infectivity of viral particles. To observe the influence of autoprocessing on the activation of recombinant HIV-1 protease, we constructed different HIV-1 pro...
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Self-cleavage at the N terminus of HIV-1 protease from the Gag-Pol precursor (autoprocessing) is crucial for stabilizing the protease dimer required for onset of mature-like catalytic activity, viral maturation, and propagation. Among nine clinical protease inhibitors (PIs), darunavir and saquinavir were the most effective in inhibiting wild-type HIV-1 group M precursor autoprocessing, with an ...
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ژورنال
عنوان ژورنال: Future Medicinal Chemistry
سال: 2013
ISSN: 1756-8919,1756-8927
DOI: 10.4155/fmc.13.89